ML417
Cat. No.：YN1730059
| 产品名称: | ML417 |
| CAS No.: | 1386162-69-1 |
| Chemical Name: | 1H-indol-2-yl[4-[2-(4-methoxyphenoxy)ethyl]-1-piperazinyl]-methanone |
| Synonyms: | ML417; ML-417; ML 417; |
| 分子量: | 379.45 |
| 分子式: | C₂₂H₂₅N₃O₃ |
| SMILES: | O=C(C(N1)=CC2=C1C=CC=C2)N3CCN(CCOC4=CC=C(OC)C=C4)CC3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ML417 是一种选择性的，可透过血脑屏障的 D3 多巴胺受体(D3R)激动剂，EC50为 38 nM。ML417 促进 D3R 介导的 β-arrestin 易位、G 蛋白介导的信号传导和 pERK 磷酸化，对其他 GPCR 介导的信号传导影响最小。ML417 对毒素诱导的多巴胺能神经元变性具有神经保护作用。 |
| IC50和靶点: | [{name:"D3 Receptor:38 nM (EC50)"}] |
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| Solvent & Solubility: |
Moritz, A.E., Free, R.B., Weiner, W.S., et al.Discovery, optimization, and characterization of ML417: A novel and highly selective D3 dopamine receptor agonistJ. Med. Chem.63(10),5526-5567(2020)
