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Pericyazine

Cat. No.:YN1730062

  • CAS No. :2622-26-6

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    • 产品名称: Pericyazine
      CAS No.: 2622-26-6
      Chemical Name: 10-[3-(4-hydroxy-1-piperidinyl)propyl]-10H-phenothiazine-2-carbonitrile
      Synonyms:Propericiazine; RP 8909
      分子量:365.49
      分子式:C₂₁H₂₃N₃OS
      SMILES:N#CC(C=C1N2CCCN3CCC(O)CC3)=CC=C1SC4=C2C=CC=C4
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Pericyazine (Propericiazine) 是第一代抗精神病药物,被用作短期管理严重焦虑状态和精神病的辅助药物。Pericyazine (Propericiazine) 是一种选择性的 D2 多巴胺受体 (D2-dopamine receptor) 拮抗剂。Pericyazine 具有肾上腺溶解、抗胆碱能和锥体外系作用。
      IC50和靶点:
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    • Kanba, S., Suzuki, E., Nomura, S., et al.Affinity of neuroleptics for D1 receptor of human brain striatumJ. Psychiatry Neurosci.19(4),265-269(1994)

      Bisson, W.H., Cheltsov, A.V., Bruey-Sedano, N., et al.Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugsProc. Natl. Acad. Sci. USA104(29),11927-11932(2007)

      Megens, A.A.H.P., Leysen, J.E., Awouters, F.H.L., et al.Further validation of in vivo and in vitro pharmacological procedures for assessing the ɑ2/ɑ1-selectivity of test compounds: (1) ɑ-adrenoceptor antagonistsEur. J. Pharmacol.129(1-2),49-55(1986)

      Ghahremanpour, M.M., Tirado-Rives, J., Deshmukh, M., et al.Identification of 14 known drugs as inhibitors of the main protease of SARS-CoV-2ACS Med. Chem. Lett.11(12),2526-2533(2020)

      Cechin, E.M., Quevedo, J., Barichello, T., et al.Dose-related effects of propericiazine in ratsBraz. J. Med. Biol. Res.36(2),227-231(2003)

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