L-745870 trihydrochloride
Cat. No.：YN1730064
| 产品名称: | L-745870 trihydrochloride |
| CAS No.: | 866021-03-6 |
| Chemical Name: | 3-(4-[4-Chlorophenyl]piperazin-1-yl)-methyl-1H-pyrrolo[2,3-b]pyridine Trihydrochloride; |
| Synonyms: | L-745870三盐酸盐,L-745,870 trihydrochloride |
| 分子量: | 436.21 |
| 分子式: | C₁₈H₂₂Cl₄N₄ |
| SMILES: | ClC(C=C1)=CC=C1N(CC2)CCN2CC3=CNC4=NC=CC=C43.Cl.Cl.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | L-745870 trihydrochloride 是一种有效的，选择性的可透过血脑屏障和具有口服活性的多巴胺D4受体拮抗剂，Ki为 0.43 nM，而对 D2(Ki为 960 nM) 和 D3(Ki为 2300 nM) 受体的亲和力相对较弱，对 5-HT2受体，sigma 位点和 α-肾上腺素受体表现出中等亲和力。 |
| IC50和靶点: | [{name:"Human D4 Receptor:4.3 nM (Ki)"},{name: "D2 Receptor:960 nM (Ki)"},{name: "D3 Receptor:2300 nM (Ki)"}] |
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| Solvent & Solubility: |
Bristow, L., et al.: Trends in Pharma. Sci., 18, 186 (1997)
Zhang, K., et al.: Neropsychopharma., 29, 1648 (2004)
