Pramipexole dihydrochloride
Cat. No.：YN1730075
CAS No. ：104632-25-9
| 产品名称: | Pramipexole dihydrochloride |
| CAS No.: | 104632-25-9 |
| Chemical Name: | (6S)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazolediamine, dihydrochloride |
| Synonyms: | 盐酸普拉克索 |
| 分子量: | 284.25 |
| 分子式: | C₁₀H₁₉Cl₂N₃S |
| SMILES: | NC(S1)=NC2=C1C[C@@H](NCCC)CC2.[H]Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pramipexole dihydrochloride 是一种 D2 型多巴胺受体 (dopamine D2-type receptor) 激动剂，对 D2 型受体、D2、D3、D4亚型受体的Ki值分别为 2.2 nM、3.9 nM、0.5 nM、1.3 nM。 Pramipexole dihydrochloride 可用于帕金森综合症和腿多动综合征的研究。Pramipexole dihydrochloride 可以透过血脑屏障。 |
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Newman-Tancredi, A., Cussac, D., Audinot, V., et al.Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. II. Agonist and antagonist properties at subtypes of dopamine D2-like receptor and α1/α2-adrenoceptorJ. Pharmacol. Exp. Ther.303(2),805-814(2002)
Millan, M.J., Maiofiss, L., Cussac, D., et al.Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypesJ. Pharmacol. Exp. Ther.303(2),791-804(2002)
Iravani, M.M., Haddon, C.O., Cooper, J.M., et al.Pramipexole protects against MPTP toxicity in non-human primatesJ. Neurochem.96(5),1315-1321(2006)
