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Dexpramipexole dihydrochloride

Cat. No.:YN1730076

  • CAS No. :104632-27-1

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    • 产品名称: Dexpramipexole dihydrochloride
      CAS No.: 104632-27-1
      Chemical Name: 4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazolediamine, dihydrochloride
      Synonyms:右旋普拉克索二盐酸盐; (R)-Pramipexole dihydrochloride; R-(+)-Pramipexole dihydrochloride; KNS-760704 dihydrochloride
      分子量:284.25
      分子式:C₁₀H₁₉Cl₂N₃S
      SMILES:NC(S1)=NC2=C1C[C@H](NCCC)CC2.[H]Cl.[H]Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Dexpramipexole dihydrochloride ((R)-Pramipexole dihydrochloride) 是神经保护剂,是弱的非麦角类多巴胺受体激动剂。
      IC50和靶点:
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    • Hametner, E.M., Seppi, K., and Poewe, W.Role and clinical utility of pramipexole extended release in the treatment of early Parkinson's diseaseClin. Interv. Aging7,83-88(2012)

      Kvernmo, T., Härtter, S., and Bürger, E.A review of the receptor-binding and pharmacokinetic properties of dopamine agonistsClin. Ther.28(8),1065-1078(2006)

      Millan, M.J., Maiofiss, L., Cussac, D., et al.Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypesJ. Pharmacol. Exp. Ther.303(2),791-804(2002)

      Newman-Tancredi, A., Cussac, D., Audinot, V., et al.Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. II. Agonist and antagonist properties at subtypes of dopamine D2-like receptor and α1/α2-adrenoceptorJ. Pharmacol. Exp. Ther.303(2),805-814(2002)

      Danzeisen, R., Schwalenstoecker, B., Gillardon, F., et al.Targeted antioxidative and neuroprotective properties of the dopamine agonist pramipexole and its nondopaminergic enantiomer SND919CL2x [(+)2-amino-4,5,6,7-tetrahydro-6-Lpropylamino-benzathiazole dihydrochloride]JPET316(1),189-199(2006)

      Chang, W.I., Weber, M., Breier, M.R., et al.Stereochemical and neuroanatomical selectivity of pramipexole effects on sensorimotor gating in ratsBrain Res.1437,69-76(2012)

      Ferrari-Toninelli, G., Maccarinelli, G., Uberti, D., et al.Mitochondria-targeted antioxidant effects of S(-) and R(+) pramipexoleBMC Pharmacol.10(2),1-6(2010)

      Abramova, N.A., Cassarino, D.S., Khan, S.M., et al.Inhibition by R(+) or S(-) pramipexole of caspase activation and cell death induced by methylpyridinium ion orβamyloid peptide in SH-SY5Y neuroblastomaJ. Neurosci. Res.67(4),494-500(2002)

      Gu, M., Iravani, M.M., Cooper, J.M., et al.Pramipexole protects against apoptotic cell death by non-dopaminergic mechanismsJ. Neurochem.91(5),1075-1081(2004)

      Cheah, B.C., and Kiernan, M.C.Dexpramipexole, the R(+) enantiomer of pramipexole, for the potential treatment of amyotrophic lateral sclerosisIDrugs.13(12),911-920(2010)

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