PD-168077 maleate
Cat. No.：YN1730087
CAS No. ：630117-19-0
| 产品名称: | PD-168077 maleate |
| CAS No.: | 630117-19-0 |
| Chemical Name: | N-[[4-(2-cyanophenyl)-1-piperazinyl]methyl]-3-methyl-benzamide, (2Z)-2-butenedioate |
| Synonyms: | PD168077; PD-168077; PD 168077; PD-168,077; PD 168,077; PD168,077; PD-168077 maleate; |
| 分子量: | 450.49 |
| 分子式: | C₂₄H₂₆N₄O₅ |
| SMILES: | O=C(NCN1CCN(C2=CC=CC=C2C#N)CC1)C3=CC=CC(C)=C3.O=C(O)/C=C\C(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PD-168077 maleate 是一个选择性的多巴胺D4受体激动剂，其Ki值为 9 nM。 |
| IC50和靶点: | |
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Glase, S.A., Akunne, H.C., Georgic, L.M., et al.Substituted [(4-phenylpiperazinyl)-methyl]benzamides: Selective dopamine D4 agonistsJ. Med. Chem.40(12),1771-1772(1997)
Gu, Z., Jiang, Q., Yuen, E.Y., et al.Activation of dopamine D4 receptors induces synaptic translocation of Ca2+/calmodulin-dependent protein kinase II in cultured prefrontal cortical neuronsMol. Pharmacol.69(3),813-822(2005)
Melis, M.R., Succu, S., Mascia, M.S., et al.PD-168077, a selective dopamine D4 receptor agonist, induces penile erection when injected into the paraventricular nucleus of male ratsNeurosci. Lett.379(1),59-62(2005)
Clifford, J.J., and Waddington, J.L.Topographically based search for an "Ethogram" among a series of novel D(4) dopamine receptor agonists and antagonistsNeuropsychopharmacology22(5),538-544(2000)
