Sumanirole maleate
Cat. No.：YN1730090
CAS No. ：179386-44-8
| 产品名称: | Sumanirole maleate |
| CAS No.: | 179386-44-8 |
| Chemical Name: | (5R)-5,6-dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one, 2Z-butenedioate |
| Synonyms: | U-95666E; PNU-95666 |
| 分子量: | 319.31 |
| 分子式: | C₁₅H₁₇N₃O₅ |
| SMILES: | O=C1NC2=C3N1C[C@H](NC)CC3=CC=C2.O=C(/C=C\C(O)=O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sumanirole maleate (U-95666E; PNU-95666E) 是高度选择性的D2 受体完全激动剂，ED50为 46 nM。Sumanirole 可用于帕金森氏病和躁动性腿综合征的研究。 |
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McCall, R.B., Lookingland, K.J., Bédard, P.J., et al.Sumanirole, a highly dopamine D2-selective receptor agonist: In vitro and in vivo pharmacological characterization and efficacy in animal models of Parkinson's diseaseJ. Pharmacol. Exp. Ther.314(3),1248-1256(2005)
Carcinella, S., Drui, G., Boulet, S., et al.Implication of dopamine D3 receptor activation in the reversion of Parkinson's disease-related motivational deficitsTransl. Psychiatry4(6),e401(2014)
Fernando, A.B., Economidou, D., Theobald, D.E., et al.Modulation of high impulsivity and attentional performance in rats by selective direct and indirect dopaminergic and noradrenergic receptor agonistsPsychopharmacology (Berl.)219(2),341-352(2012)
