Pramipexole
Cat. No.：YN1730095
| 产品名称: | Pramipexole |
| CAS No.: | 104632-26-0 |
| Chemical Name: | (S)-4,5,6,7-Tetrahydro-N6-propyl-2,6-benzothiazolediamine |
| Synonyms: | 普拉克索 |
| 分子量: | 211.33 |
| 分子式: | C₁₀H₁₇N₃S |
| SMILES: | NC1=NC(CC[C@H](NCCC)C2)=C2S1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pramipexole 是一种选择性的 D2 型多巴胺受体 (dopamine D2-type receptor) 激动剂，对 D2 型受体、D2、D3、D4亚型受体的Ki值分别为 2.2 nM、3.9 nM、0.5 nM、1.3 nM。 Pramipexole 可用于帕金森综合症和腿多动综合征的研究。Pramipexole 可以透过血脑屏障。 |
| IC50和靶点: | [{name:"D2 Receptor:3.9 nM (Ki)"},{name: "D3 Receptor:0.5 nM (Ki)"},{name: "D4 Receptor:1.3 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Mierau, J., et al.: J. Med. Chem., 30, 494 (1987), Schilling, J.C., et al.: Clin. Pharmacol. Ther., 51, 541 (1992), Kieburtz, K., et al.: J. Am. Med. Assoc., 278, 125 (1997)
