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Domperidone

Cat. No.:YN1730097

  • CAS No. :57808-66-9

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    • 产品名称: Domperidone
      CAS No.: 57808-66-9
      Chemical Name: 5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one
      Synonyms:多潘立酮; R33812
      分子量:425.91
      分子式:C₂₂H₂₄ClN₅O₂
      SMILES:O=C1NC2=CC(Cl)=CC=C2N1C3CCN(CCCN4C5=CC=CC=C5NC4=O)CC3
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Domperidone (R33812) 是一种多巴胺 2 受体 (dopamine-2 receptor) 拮抗剂。Domperidone 通过影响胃和小肠的化学感受器触发区和运动功能,起到止吐和促动力作用。
      IC50和靶点:
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    • Sokoloff, P., Giros, B., Martres, M.P., et al.Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neurolepticsNature137(6289),146-151(1990)

      Kohli, J.D., Glock, D., and Goldberg, L.I.Selective DA2 versus DA1 antagonist activity of domperidone in the peripheryEur. J. Pharmacol.89(1-2),137-141(1983)

      Bech, K., Hovendal, C.P., and Andersen, D.Effect of dopamine on pentagastrin-stimulated gastric antral motility in dogs with gastric fistulaScand. J. Gastroenterol.17(1),103-107(1982)

      Niemegeers, C.J.E.Antiemetic specificity of dopamine antagonistsPsychopharmacology (Berl.)78(3),210-213(1982)

      Meltzer, H.Y., Simonovic, M., and So, R.Effects of a series of substituted benzamides on rat prolactin secretion and 3H-spiperone binding to bovine anterior pituitary membranesLife Sci.32(25),2877-2886(1983)

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