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Droperidol

Cat. No.:YN1730107

  • CAS No. :548-73-2

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    • 参考文献
    • 产品名称: Droperidol
      CAS No.: 548-73-2
      Chemical Name: 1-[1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl]-1,3-dihydro-2H-benzimidazol-2-one
      Synonyms:氟哌啶; Dehydrobenzperidol
      分子量:379.43
      分子式:C₂₂H₂₂FN₃O₂
      SMILES:O=C1NC2=CC=CC=C2N1C3=CCN(CCCC(C4=CC=C(F)C=C4)=O)CC3
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Droperidol是一种丁酰苯类的Dopamine-2受体拮抗剂。
      IC50和靶点:
      In Vitro:
      In Vivo:
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      Solvent & Solubility:
    • Seeman, P., and Tallerico, T.Antipsychotic drugs which elicit little or no parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptorsMol. Psychiatry3(2),123-134(2016)

      Rajamani, R., Tounge, B.A., Li, J., et al.A two-state homology model of the hERG K+ channel: Application to ligand bindingBioorg. Med. Chem. Lett.15(6),1737-1741(2005)

      Leysen, J.E., Janssen, P.M.F., Schotte, A., et al.Interaction of antipsychotic drugs with neurotransmitter receptor sites in vitro and in vivo in relation to pharmacological and clinical effects: Role of 5HT2 receptorsPsychopharmacology (Berl)112(1 Suppl),S40-S54(1993)

      Wojtczak, J., and Beresewicz, A.Electrophysiological effects of the neuroleptanalgesic drugs on the canine cardiac tissueNaunyn Schmiedebergs Arch Pharmacol.286(2),211-220(1974)

      Niemegeers, C.J.E.Antiemetic specificity of dopamine antagonistsPsychopharmacology (Berl.)78(3),210-213(1982)

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