Vanoxerine dihydrochloride
Cat. No.：YN1730056
| 产品名称: | Vanoxerine dihydrochloride |
| CAS No.: | 67469-78-7 |
| Chemical Name: | 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)-piperazine, dihydrochloride |
| Synonyms: | GBR-12909 dihydrochloride; I893 dihydrochloride |
| 分子量: | 523.49 |
| 分子式: | C₂₈H₃₄Cl₂F₂N₂O |
| SMILES: | FC1=CC=C(C(C2=CC=C(F)C=C2)OCCN3CCN(CCCC4=CC=CC=C4)CC3)C=C1.[2HCl] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) 是竞争性的，有效选择性的多巴胺再摄取(dopamine reuptake)抑制剂。Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) 与多巴胺转运体 (DAT) 上的靶点结合。 |
| IC50和靶点: | |
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Heikkila, R.E., and Manzino, L.Behavioral properties of GBR 12909, GBR 13069 and GBR 13098: Specific inhibitors of dopamine uptakeEur. J. Pharmacol.103(3-4),241-248(1984)
Andersen, P.H.The dopamine uptake inhibitor GBR 12909: Selectivity and molecular mechanism of actionEur. J. Pharmacol.166(3),493-504(1989)
Melia, K.F., and Spealman, R.D.Pharmacological characterization of the discriminative-stimulus effects of GBR 12909J. Pharmacol. Exp. Ther.258(2),626-632(1991)
Contreras, P.C., Bremer, M.E., and Rao, T.S.GBR-12909 and fluspirilene potently inhibited binding of [3H](+)3-PPP to sigma receptors in rat brainLife Sci.47(22),PL133-PL137(1990)
