Diclofensine hydrochloride
Cat. No.：YN1730078
| 产品名称: | Diclofensine hydrochloride |
| CAS No.: | 34041-84-4 |
| Chemical Name: | 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-7-methoxy-2-methyl-isoquinoline, monohydrochloride |
| Synonyms: | Ro 8-4650 hydrochloride |
| 分子量: | 358.69 |
| 分子式: | C₁₇H₁₈Cl₃NO |
| SMILES: | CN1CC2=C(C=CC(OC)=C2)C(C3=CC=C(Cl)C(Cl)=C3)C1.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Diclofensine hydrochloride (Ro-8-4650 hydrochloride) 是高效单胺再摄取抑制剂，大鼠脑突触体中阻断多巴胺、去甲肾上腺素和5-羟色胺的IC50值分别为0.74、2.3和3.7nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Hyttel, J., and Larsen, J.J.Neurochemical profile of Lu 19-005, a potent inhibitor of uptake of dopamine, noradrenaline, and serotoninJ. Neurochem.44(5),1615-1622(1985)
Jackson, S.H., Turner, P., and Ehsanullah, R.S.A comparison of diclofensine and desmethylimipramine using tyramine pressor tests in normal subjectsBr. J. Clin. Pharmacol.16(4),427-429(1983)
Cilug, J., Ehsanullah, R.S., Hallett, C., et al.A clinical pharmacological comparison of diclofensine (Ro 8-4650) with nomifensine and amitriptyline in normal human volunteersBr. J. Clin. Pharmacol.15(5),537-543(1983)
Lamb, R.J., and Griffiths, R.R.Self-administration in baboons and the discriminative stimulus effects in rats of bupropion, nomifensine, diclofensine and imipraminePsychopharmacology (Berl)102(2),183-190(1990)
Nakachi, N., Kiuchi, Y., Inagaki, M., et al.Effects of various dopamine uptake inhibitors on striatal extracellular dopamine levels and behaviours in ratsEur. J. Pharmacol.281(2),195-203(1995)
