Hydroxy-Dynasore
Cat. No.：YN300032
CAS No. ：1256493-34-1
| 产品名称: | Hydroxy-Dynasore |
| CAS No.: | 1256493-34-1 |
| Chemical Name: | 3-hydroxy-2-naphthalenecarboxylic acid, 2-[(2,4,5-trihydroxyphenyl)methylene]hydrazide |
| Synonyms: | Dyngo-4a |
| 分子量: | 338.31 |
| 分子式: | C₁₈H₁₄N₂O₅ |
| SMILES: | OC1=CC2=CC=CC=C2C=C1C(N/N=C/C3=C(O)C=C(O)C(O)=C3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Hydroxy Dynasore (Dyngo-4a) 是 Dynasore (HY-15304) 结构模拟类似物，是一种改进的，低细胞毒性和通用的dynamin抑制剂，针对大脑重组 dynamin I 和重组鼠 dynamin II 的IC50值分别为 0.38 μM 和 2.3μM。Hydroxy Dynasore 抑制 dynamin 依赖性转铁蛋白的内吞作用 (endocytosis) 的IC50为 5.7 μM。 |
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McCluskey, A., Daniel, J.A., Hadzic, G., et al.Building a better dynasore: The dyngo compounds potently inhibit dynamin and endocytosisTraffic14(12),1272-1289(2013)
Mohanakrishnan, A., Tran, T.V.M., Kumar, M., et al.A highly-sensitive high throughput assay for dynamin's basal GTPase activityPLoS One12(9),e0185639(2017)
