Dynole 34-2
Cat. No.：YN300086
CAS No. ：1128165-88-7
| 产品名称: | Dynole 34-2 |
| CAS No.: | 1128165-88-7 |
| Chemical Name: | 2-cyano-3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-N-octyl-2-propenamide |
| Synonyms: | |
| 分子量: | 408.5797 |
| 分子式: | C25H36N4O |
| SMILES: | N#CC(C(NCCCCCCCC)=O)=CC1=CN(CCCN(C)C)C2=C1C=CC=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Dynole 34-2 是一种dynaminGTPase抑制剂(对dynamin1 和dynamin2 GTPase 活性的IC50s 分别为 6.9 和 14.2 µM)，具有抗有丝分裂的作用。Dynole 34-2 诱导细胞凋亡，如细胞空泡、DNA断裂和PARP剪切。Dynole 34-2 也能有效抑制受体介导的内吞作用 (RME)。 |
| IC50和靶点: | |
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Chircop, M., Pera, S., Mariana, A., et al.Inhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cellsMol. Cancer Ther.10(9),1553-1562(2011)
