Aficamten
Cat. No.：YN300093
CAS No. ：2364554-48-1
| 产品名称: | Aficamten |
| CAS No.: | 2364554-48-1 |
| Chemical Name: | N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methyl-1H-pyrazole-4-carboxamide |
| Synonyms: | CK-274; CK-3773274 |
| 分子量: | 337.37596 |
| 分子式: | C18H19N5O2 |
| SMILES: | O=C(C1=CN(C)N=C1)N[C@H]2C3=CC=C(C4=NOC(CC)=N4)C=C3CC2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Aficamten (CK-274) 是一种新型心肌肌球蛋白 (cardiacmyosin)抑制剂，IC50为 1.4 μM。Aficamten 可用于肥厚型心肌病 (HCM) 的研究。 |
| IC50和靶点: | |
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Chuang, C., Collibee, S., Ashcraft, L., et al.Discovery of aficamten (CK-274), a next-generation cardiac myosin inhibitor for the treatment of hypertrophic cardiomyopathyJ. Med. Chem.64(19),14142-14152(2021)
