PLN-1474
Cat. No.：YN300094
CAS No. ：2408065-32-5
| 产品名称: | PLN-1474 |
| CAS No.: | 2408065-32-5 |
| Chemical Name: | |
| Synonyms: | |
| 分子量: | 431.57 |
| 分子式: | C24H37N3O4 |
| SMILES: | O=C(O)[C@H](CCCCCCCC1=CC=C2C(N1)=NCCC2)NC(C3(C)CCOCC3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PLN-1474 (compound 1) 是具有口服活性的，选择性的av 1 整合素抑制剂，IC50值 ＜50 nM。PLN-1474 在肝纤维化小鼠模型中显著降低肝脏 pSMAD3/SMAD3 水平、肝脏胶原蛋白基因表达和肝脏 OHP 浓度。PLN-1474 可用于预防、延缓或研究纤维化或肝硬化疾病或紊乱的研究。 |
| IC50和靶点: | |
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