Wiskostatin
Cat. No.：YN300096
CAS No. ：253449-04-6
| 产品名称: | Wiskostatin |
| CAS No.: | 253449-04-6 |
| Chemical Name: | 3,6-dibromo-α-[(dimethylamino)methyl]-9H-carbazole-9-ethanol |
| Synonyms: | |
| 分子量: | 426.1 |
| 分子式: | C17H18Br2N2O |
| SMILES: | OC(CN(C)C)CN1C2=CC=C(Br)C=C2C3=C1C=CC(Br)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Wiskostatin 是一种有效且选择性的神经元 Wiskott-Aldrich 综合征蛋白 (N-WASP) 介导的肌动蛋白聚合抑制剂。Wiskostatin 会导致细胞 ATP 水平快速、深刻且不可逆地下降。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Leung, D.W., Morgan, D.M., and Rosen, M.K.Biochemical properties and inhibitors of (N-)WASPMethods Enzymol.406,281-296(2006)
Peterson, J.R., Bickford, L.C., Morgan, D., et al.Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformationNat. Struct. Mol. Biol.11(8),747-755(2004)
Guerriero, C.J., and Weisz, O.A.N-WASP inhibitor wiskostatin nonselectively perturbs membrane transport by decreasing cellular ATP levelsAm. J. Physiol. Cell Physiol.292(4),C1562-C1566(2007)
Welliver, T.P., Chang, S.L., Linderman, J.J., et al.Ruffles limit diffusion in the plasma membrane during macropinosome formationJ. Cell Sci.124(23),4106-4114(2011)
Wegner, A.M., Nebhan, C.A., Hu, L., et al.N-WASP and the Arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapsesJ. Biol. Chem.283(23),15912-15920(2008)
