A-286982
Cat. No.：YN300098
CAS No. ：280749-17-9
| 产品名称: | A-286982 |
| CAS No.: | 280749-17-9 |
| Chemical Name: | (2E)-1-(4-acetyl-1-piperazinyl)-3-[4-[[2-(1-methylethyl)phenyl]thio]-3-nitrophenyl]-2-propen-1-one |
| Synonyms: | A 286982;A-286982;(E)-1-(4-acetylpiperazin-1-yl)-3-[3-nitro-4-(2-propan-2-ylphenyl)sulfanylphenyl]prop-2-en-1-one;(2E)-1-(4-Acetyl-1-piperazinyl)-3-[4-[[2-(1-methylethyl)phenyl]thio]-3-nitrophenyl]-2-propen-1-one |
| 分子量: | 453.555 |
| 分子式: | C24H27N3O4S |
| SMILES: | CC(C)C1=C(SC2=C([N+]([O-])=O)C=C(/C=C/C(N3CCN(C(C)=O)CC3)=O)C=C2)C=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | A-286982 是一种有效的变构LFA-1/ICAM-1相互作用抑制剂，在 LFA-1/ICAM-1 结合和 LFA-1 介导的细胞粘附试验中，IC50分别为 44 nM 和 35 nM。 |
| IC50和靶点: | |
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Liu, G., Link, J.T., Pei, Z., et al.Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide leadJ. Med. Chem.43(21),4025-4040(2000)
