Levocabastine hydrochloride
Cat. No.：YN300103
| 产品名称: | Levocabastine hydrochloride |
| CAS No.: | 79547-78-7 |
| Chemical Name: | (3S,4R)-1-[cis-4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-4-piperidinecarboxylic acid, monohydrochloride |
| Synonyms: | R 50547 hydrochloride |
| 分子量: | 457 |
| 分子式: | C26H29FN2O2 • HCl |
| SMILES: | FC(C=C1)=CC=C1[C@@](CC2)(C#N)CC[C@@H]2N(C[C@H]3C)CC[C@]3(C(O)=O)C4=CC=CC=C4.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Levocabastine (R 50547) hydrochloride 是一种强效选择性组胺 H1 受体拮抗剂。Levocabastine hydrochloride 也是一种选择性、高亲和力的神经降压素受体亚型 2(NTR2)拮抗剂，对 mNTR2 的Ki值为 17 nM。Levocabastine hydrochloride 可作为VLA-4拮抗剂，干扰过敏性结膜炎 (AC) 结膜嗜酸性粒细胞的浸润。 |
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Sharif, N.A., Xu, S.X., and Yanni, J.M.Olopatadine (AL-4943A): Ligand binding and functional studies on a novel, long acting H1-selective histamine antagonist and anti-allergic agent for use in allergic conjunctivitisJ. Ocul. Pharmacol. Ther.12(4),401-407(1996)
Chalon, P., Vita, N., Kaghad, M., et al.Molecular cloning of a levocabastine-sensitive neurotensin binding siteFEBS Lett.386(2-3),91-94(1996)
Minami, K., Hossen, M.A., and Kamei, C.Increasing effect by simultaneous use of levocabastine and pemirolast on experimental allergic conjunctivitis in ratsBiol. Pharm. Bull.28(3),473-476(2005)
