(S,R,S)-AHPC-PEG4-NH2 hydrochloride
Cat. No.：YN430018
CAS No. ：2064292-52-8
| 产品名称: | (S,R,S)-AHPC-PEG4-NH2 hydrochloride |
| CAS No.: | 2064292-52-8 |
| Chemical Name: | (2S,4R)-1-((S)-17-amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, monohydrochloride |
| Synonyms: | VH032-PEG4-NH2 hydrochloride; VHL Ligand-Linker Conjugates 4 hydrochloride; E3 ligase Ligand-Linker Conjugates 7 |
| 分子量: | 700.29 |
| 分子式: | C₃₂H₅₀ClN₅O₈S |
| SMILES: | O=C(N[C@@H](C(C)(C)C)C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)=O)COCCOCCOCCOCCN.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (S,R,S)-AHPC-PEG4-NH2 hydrochloride 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 (S,R,S)-AHPC 的 VHL 配体和 4 个单元 PEG linker。 |
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Chan, K.H., Zengerle, M., and Ciulli, A.Impact of target warhead and linkage vector on inducing protein degradation: Comparison of bromodomain and extra-terminal (BET) degraders derived from triazolodiazepine (JQ1) and tetrahydroquinoline (I-BET726) BET inhibitor scaffoldsJ. Med. Chem.61(2),504-513(2018)
