Thalidomide-O-amido-C4-N3
Cat. No.：YN430028
CAS No. ：2098488-36-7
规格
价格(RMB)
库存
| 产品名称: | Thalidomide-O-amido-C4-N3 |
| CAS No.: | 2098488-36-7 |
| Chemical Name: | N-(4-azidobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-acetamide |
| Synonyms: | Cereblon Ligand-Linker Conjugates 4; E3 ligase Ligand-Linker Conjugates 18 |
| 分子量: | 428.40 |
| 分子式: | C₁₉H₂₀N₆O₆ |
| SMILES: | O=C(N(C(CCC1=O)C(N1)=O)C2=O)C(C2=CC=C3)=C3OCC(NCCCCN=[N+]=[N-])=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Thalidomide-O-amido-C4-N3 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 Thalidomide 的 cereblon 配体和 1 个 linker。 |
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Schiedel, M., Herp, D., Hammelmann, S., et al.Chemically induced degradation of Sirtuin 2 (Sirt2) by a proteolysis targeting chimera (PROTAC) based on sirtuin rearranging ligands (SirReals)J. Med. Chem.61(2),482-491(2018)
