DL-TBOA
Cat. No.：YN360185
| 产品名称: | DL-TBOA |
| CAS No.: | 205309-81-5 |
| Chemical Name: | rel-3R-(phenylmethoxy)-D-aspartic acid |
| Synonyms: | |
| 分子量: | 239.22 |
| 分子式: | C₁₁H₁₃NO₅ |
| SMILES: | OC([C@@H](N)[C@@H](C(O)=O)OCC1=CC=CC=C1)=O.[Relative stereochemistry] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | DL-TBOA 是一种有效的不可运输的兴奋性氨基酸转运蛋白抑制剂，对兴奋性氨基酸转运蛋白 1 (EAAT1)，EAAT2和EAAT3的IC50值分别为 70 μM，6 μM 和 6 μM。DL-TBOA 抑制表达人EAAT1和EAAT2的 COS-1 细胞摄取 [14C]谷氨酸，Ki值分别为 42 μM 和 5.7 μM。DL-TBOA 以竞争性方式阻断EAAT4和EAAT5，Ki值分别为 4.4 μM 和 3.2 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Shimamoto, K., Lebrun, B., Yasuda-Kamatani, Y., et al.ᴅʟ-threo-β-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters.Mol. Pharmacol.53(2),195-201(1998)
Shigeri, Y., Shimamoto, K., Yasuda-Kamatani, Y., et al.Effects of threo-β-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5)J. Neurochem.79(2),297-302(2001)
Montiel, T., Camacho, A., Estrada-Sánchez, A.M., et al.Differential effects of the substrate inhibitor ʟ-trans-pyrrolidine-2,4-dicarboxylate (PDC) and the non-substrate inhibitor ᴅʟ-threo-β-benzyloxyaspartate (ᴅʟ-TBOA) of glutamate transporters on neuronal damage and extracellular amino acid levels in rat brain in vivoNeuroscience133(3),667-678(2005)
Yaster, M., Guan, X., Petralia, R.S., et al.Effect of inhibition of spinal cord glutamate transporters on inflammatory pain induced by formalin and complete Freund's adjuvantAnesthesiology114(2),412-423(2011)
