GT 949
Cat. No.：YN360288
CAS No. ：460330-27-2
| 产品名称: | GT 949 |
| CAS No.: | 460330-27-2 |
| Chemical Name: | 3-[(4-cyclohexyl-1-piperazinyl)[1-(2-phenylethyl)-1H-tetrazol-5-yl]methyl]-6-methoxy-2(1H)-quinolinone |
| Synonyms: | GT 949 |
| 分子量: | 527.66 |
| 分子式: | C₃₀H₃₇N₇O₂ |
| SMILES: | O=C1NC2=C(C=C(OC)C=C2)C=C1C(N3CCN(C4CCCCC4)CC3)C5=NN=NN5CCC6=CC=CC=C6 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GT 949 是一种选择性的兴奋性氨基酸转运蛋白-2 (EAAT2) 阳性变构调节剂，EC50为 0.26 nM。 |
| IC50和靶点: | |
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Kortagere, S., Mortensen, O.V., Xia, J., et al.Identification of novel allosteric modulators of glutamate transporter EAAT2ACS Chem. Neurosci.9(3),522-534(2018)
Falcucci, R.M., Wertz, R., Green, J.L., et al.Novel positive allosteric modulators of glutamate transport have neuroprotective properties in an in vitro excitotoxic modelACS Chem. Neurosci.10(8),3437-3453(2019)
