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Budesonide

Cat. No.:YN320760

  • CAS No. :51333-22-3

    • 产品资料
    • 生物活性
    • 参考文献
    • 产品名称: Budesonide
      CAS No.: 51333-22-3
      Chemical Name: 16α,17-[butylidenebis(oxy)]-11β,21-dihydroxy-pregna-1,4-diene-3,20-dione
      Synonyms:布地奈德
      分子量:430.53
      分子式:C₂₅H₃₄O₆
      SMILES:O=C(C=C[C@@]12C)C=C1CC[C@@]([C@]2([H])[C@@H](O)C[C@@]34C)([H])[C@]3([H])C[C@]5([H])[C@@]4(C(CO)=O)OC(CCC)O5
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Budesonide 是一种吸入型糖皮质类固醇,具有口服活性的糖皮质激素受体 (glucocorticoid receptor) 激动剂。Budesonide 可减少肺部肿瘤的大小,逆转 DNA 低度甲基化并调节基因的 mRNA 表达。Budesonide 是一种可以用于哮喘的抗炎药。
      IC50和靶点:
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      In Vivo:
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      Solvent & Solubility:
    • Grossmann, C., Scholz, T., Rochel, M., et al.Transactivation via the human glucocorticoid and mineralocorticoid receptor by therapeutically used steroids in CV-1 cells: A comparison of their glucocorticoid and mineralocorticoid propertiesEur. J. Endocrinol.151(3),397-406(2004)

      Millan, D.S., Ballard, S.A., Chunn, S., et al.Design and synthesis of long acting inhaled corticosteroids for the treatment of asthmaBioorg. Med. Chem. Lett.21(19),5826-5830(2011)

      Birrell, M.A., Hardaker, E., Wong, S., et al.IκB kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthmaAm. J. Respir. Crit. Care Med.172(8),962-971(2005)

      Ekström, G.M.Oxazolone-induced colitis in rats: effects of budesonide, cyclosporin A, and 5-aminosalicylic acidScand. J. Gastroenterol.33(2),174-179(1998)

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