LY3214996
Cat. No.：YN350012
CAS No. ：1951483-29-6
| 产品名称: | LY3214996 |
| CAS No.: | 1951483-29-6 |
| Chemical Name: | 5,6-dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one |
| Synonyms: | LY3214996 |
| 分子量: | 453.56 |
| 分子式: | C₂₂H₂₇N₇O₂S |
| SMILES: | O=C(C(C=C(C1=NC(NC2=CC=NN2C)=NC=C1)S3)=C3C4(C)C)N4CCN5CCOCC5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LY3214996 是高效的选择性ERK1和ERK2抑制剂，IC50为 5 nM。LY3214996 作用于 BRAF 和 RAS 突变癌细胞系中，有效抑制 p-RSK1。LY3214996 在 MAPK 途径改变的癌症模型中具有强大的抗肿瘤活性。 |
| IC50和靶点: | [{name:"ERK1:5 nM (IC50)"},{name: "ERK2:5 nM (IC50)"}] |
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Bhagwat, S.V., McMillen, W.T., Cai, S., et al.Abstract 4973: Discovery of LY3214996, a selective and novel ERK1/2 inhibitor with potent antitumor activities in cancer models with MAPK pathway alterationsCancer Res.77(Suppl. 13),(2017)
