AG126
Cat. No.：YN350055
CAS No. ：118409-62-4
| 产品名称: | AG126 |
| CAS No.: | 118409-62-4 |
| Chemical Name: | 2-[(3-hydroxy-4-nitrophenyl)methylene]-propanedinitrile |
| Synonyms: | AG 126; AG126; AG-126 |
| 分子量: | 215.17 |
| 分子式: | C₁₀H₅N₃O₃ |
| SMILES: | N#C/C(C#N)=C/C1=CC=C([N+]([O-])=O)C(O)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AG126 是酪氨酸激酶抑制剂，可以阻止丝裂原活化蛋白激酶p42MAPK(ERK2) 的激活。 |
| IC50和靶点: | |
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Novogrodsky, A., Vanichkin, A., Patya, M., et al.Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitorsScience264(5163),1319-1322(1994)
Hanisch, U.K., Prinz, M., Angstwurm, K., et al.The protein tyrosine kinase inhibitor AG126 prevents the massive microglial cytokine induction by pneumococcal cell wallsEur. J. Immunol.31(7),2104-2115(2001)
Cuzzocrea, S., McDonald, M.C., Mazzon, E., et al.The tyrosine kinase inhibitor tyrphostin AG126 reduces the development of acute and chronic inflammationAm. J. Pathol.157(1),145-158(2000)
Ruetten, H., and Thiemermann, C.Effects of tyrphostins and genistein on the circulatory failure and organ dysfunction caused by endotoxin in the rat: A possible role for protein tyrosine kinaseBr. J. Pharmacol.122(1),59-70(1997)
Chatterjee, P.K., Patel, N.S.A., Kvale, E.O., et al.The tyrosine kinase inhibitor tyrphostin AG126 reduces renal ischemia/reperfusion injury in the ratKidney Int.64(5),1605-1619(2003)
Gazit, A., Yaish, P., Gilon, C., et al.Tyrphostins I: Synthesis and biological activity of protein tyrosine kinase inhibitorsJ. Med. Chem.32(10),2344-2352(1989)
Sagara, Y., Ishige, K., Tsai, C., et al.Tyrphostins protect neuronal cells from oxidative stressJ. Biol. Chem.277(39),36204-36215(2002)
