AZD-0364
Cat. No.：YN350071
| 产品名称: | AZD-0364 |
| CAS No.: | 2097416-76-5 |
| Chemical Name: | (6R)-7-[(3,4-difluorophenyl)methyl]-6,7-dihydro-6-(methoxymethyl)-2-[5-methyl-2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-imidazo[1,2-a]pyrazin-8(5H)-one |
| Synonyms: | AZD-0364 |
| 分子量: | 494.50 |
| 分子式: | C₂₄H₂₄F₂N₈O₂ |
| SMILES: | O=C1C2=NC(C3=NC(NC4=CC=NN4C)=NC=C3C)=CN2C[C@H](COC)N1CC5=CC=C(F)C(F)=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AZD-0364 是一种有效的选择性ERK2抑制剂，IC50为 0.6 nM。详细信息请参考专利文献 WO2017080979A1 中的化合物 example 18。 |
| IC50和靶点: | [{name:"ERK2:0.6 nM (IC50)"}] |
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| Solvent & Solubility: |
Ward, R.A., Anderton, M.J., Bethel, P.A., et al.Discovery of a potent and selective oral inhibitor of ERK1/2 (AZD0364) that is efficacious in both monotherapy and combination therapy in models of nonsmall cell lung cancer (NSCLC)J. Med. Chem.62(24),11004-11018(2019)
Ward, R.A., Jones, C.D., Swallow, S., et al.Dihydroimidazopyrazinone derivatives useful in the treatment of cancer,(2017)
