KO-947
Cat. No.：YN350078
CAS No. ：1695533-89-1
| 产品名称: | KO-947 |
| CAS No.: | 1695533-89-1 |
| Chemical Name: | 1,5,6,8-tetrahydro-6-(phenylmethyl)-3-(4-pyridinyl)-7H-pyrazolo[4,3-g]quinazolin-7-one |
| Synonyms: | KO-947;KO947;6-benzyl-3-(pyridin-4-yl)-5,6-dihydro-1H-pyrazolo[4,3-g]quinazolin-7(8H)-one;GTPL9976;BCP25116;VSC53389;ZB1531;A929347;6-benzyl-3-pyridin-4-yl-2,5-dihydro-1H-pyrazolo[4,3-g]quinazolin-7-one;6-benzyl-3-pyridin-4-yl-5,8-dihydro-1H-pyrazolo[4,3- |
| 分子量: | 355.39 |
| 分子式: | C₂₁H₁₇N₅O |
| SMILES: | O=C1NC2=CC(NN=C3C4=CC=NC=C4)=C3C=C2CN1CC5=CC=CC=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | KO-947是有效和选择性的ERK1/2激酶抑制剂，在MAPK途径失调的肿瘤中具有潜在效用。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Burrows, F., Kessler, L., Chen, J., et al.Abstract 5168: KO-947, a potent ERK inhibitor with robust preclinical single agent activity in MAPK pathway dysregulated tumorsCancer Res.77(13 Suppl.),5168-5168(2017)
Li, L., Wu, T., Feng, J., et al.Inhibitors of ERK and methods of use ,(2015)
