BIX02188
Cat. No.：YN350097
CAS No. ：334949-59-6
| 产品名称: | BIX02188 |
| CAS No.: | 334949-59-6 |
| Chemical Name: | (3Z)-3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide |
| Synonyms: | BIX 02188;BIX-02188;(3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide;BIX02188 |
| 分子量: | 412.48 |
| 分子式: | C₂₅H₂₄N₄O₂ |
| SMILES: | O=C(N)C1=CC(NC2=O)=C(/C2=C(C3=CC=CC=C3)/NC4=CC=CC(CN(C)C)=C4)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BIX02188 是一种有效的选择性MEK5抑制剂，IC50为 4.3 nM。 BIX02188 也选择性抑制ERK5活性, IC50为 810 nM。 |
| IC50和靶点: | [{name:"MEK5:4.3 nM (IC50)"},{name: "ERK5:810 nM (IC50)"},{name: "CSF1R (FMS):280 nM (IC50)"},{name: "LCK:390 nM (IC50)"},{name: "KIT:550 nM (IC50)"},{name: "TGFβR1:1.8 μM (IC50)"},{name: "ABL1:2.1 μM (IC50)"},{name: "RPS6KA6 (RSK4):3.2 μM (IC50)"},{name: "RPS6KA3 (RSK2):4.1 μM (IC50)"},{name: "MAPK14 (p38 alpha):3.9 μM (IC50)"},{name: "JAK3:7.8 μM (IC50)"},{name: "SRC:8.9 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Tatake, R.J., O'Neill, M.M., Kennedy, C.A., et al.Identification of pharmacological inhibitors of the MEK5/ERK5 pathwayBiochem. Biophys. Res. Commun.377(1),120-125(2008)
