BIX02189
Cat. No.：YN350098
CAS No. ：1265916-41-3
| 产品名称: | BIX02189 |
| CAS No.: | 1265916-41-3 |
| Chemical Name: | (3Z)-3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide |
| Synonyms: | BIX 02189 |
| 分子量: | 440.54 |
| 分子式: | C₂₇H₂₈N₄O₂ |
| SMILES: | O=C(N(C)C)C1=CC(NC2=O)=C(/C2=C(C3=CC=CC=C3)/NC4=CC=CC(CN(C)C)=C4)C=C1.[(Z)] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BIX02189 是一种有效的选择性MEK5抑制剂，IC50为 1.5 nM。BIX02189 也抑制ERK5活性，IC50为 59 nM。 |
| IC50和靶点: | [{name:"MEK5:1.5 nM (IC50)"},{name: "ERK5:59 nM (IC50)"},{name: "CSF1R (FMS):46 nM (IC50)"},{name: "LCK:250 nM (IC50)"},{name: "JAK3:440 nM (IC50)"},{name: "TGFβR1:580 nM (IC50)"},{name: "RPS6KA6 (RSK4):990 nM (IC50)"},{name: "RPS6KA3 (RSK2):2.1 μM (IC50)"},{name: "FGFR1:1 μM (IC50)"},{name: "KIT:1.1 μM (IC50)"},{name: "ABL1:2.4 μM (IC50)"},{name: "MAPK14 (p38 alpha):3.7 μM (IC50)"},{name: "SRC:7.6 μM (IC50)"}] |
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| Solvent & Solubility: |
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Obara, Y., and Nakahata, N.The signaling pathway leading to extracellular signal-regulated kinase 5 (ERK5) activation via G-proteins and ERK5-dependent neurotrophic effectsMol. Pharmacol.77(1),10-16(2010)
Wang, X., Pesakhov, S., Weng, A., et al.ERK 5/MAPK pathway has a major role in 1a,25-(OH)2 vitamin D3-induced terminal differentiation of myeloid leukemia cellsJ. Steroid Biochem. Mol. Biol.144(Pt. A),223-227(2014)
