FR 180204
Cat. No.：YN350107
CAS No. ：865362-74-9
| 产品名称: | FR 180204 |
| CAS No.: | 865362-74-9 |
| Chemical Name: | 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-amine |
| Synonyms: | FR180204 |
| 分子量: | 327.34 |
| 分子式: | C₁₈H₁₃N₇ |
| SMILES: | NC1=NNC2=NN=C(C3=C4C=CC=CN4N=C3C5=CC=CC=C5)C=C21 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | FR 180204 是一种 ATP 竞争性的选择性ERK抑制剂，对ERK1和ERK2的Ki值分别为 0.31 μM 和 0.14 μM。IC50值分别为0.51 μM 和0.33 μM。 |
| IC50和靶点: | [{name:"ERK2:0.14 μM (Ki)"},{name: "ERK1:0.31 μM (Ki)"},{name: "ERK2:0.33 μM (IC50)"},{name: "ERK1:0.51 μM (IC50)"}] |
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| Solvent & Solubility: |
Ohori, M., Kinoshita, T., Okubo, M., et al.Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complexBiochem. Biophys. Res. Commun.336(1),357-363(2005)
Ohori, M., Takeuchi, M., Maruki, R., et al.FR180204, a novel and selective inhibitor of extracellular signal-regulated kinase, ameliorates collagen-induced arthritis in miceNaunyn Schmiedebergs Arch. Pharmacol.374(4),311-316(2007)
