ERK1/2 inhibitor 2
Cat. No.：YN350116
CAS No. ：2095719-92-7
| 产品名称: | ERK1/2 inhibitor 2 |
| CAS No.: | 2095719-92-7 |
| Chemical Name: | (αR)-6-[5-chloro-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-N-[(1S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl]-1,3-dihydro-α-methyl-1-oxo-2H-isoindole-2-acetamide |
| Synonyms: | ASTX029,ASTX-029 |
| 分子量: | 584.04 |
| 分子式: | C₂₉H₃₁ClFN₅O₅ |
| SMILES: | ClC(C(C1=CC2=C(CN([C@H](C)C(N[C@H](CO)C3=CC(F)=CC(OC)=C3)=O)C2=O)C=C1)=N4)=CN=C4NC5CCOCC5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ERK1/2 inhibitor 2 (Example 1) 是有效的ERK1/2双重抑制剂。ERK1/2 inhibitor 2 具有抗癌活性。 |
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Munck, J., Berdini, V., Courtin, A., et al.The clinical candidate, ASTX029, is a novel, dual mechanism ERK1/2 inhibitor and has potent activity in MAPK-activated cancer cell lines and in vivo tumor modelsEur. J. Cancer138(Suppl 2),S53(2020)
