ERK5-IN-2
Cat. No.：YN350122
CAS No. ：1888305-96-1
| 产品名称: | ERK5-IN-2 |
| CAS No.: | 1888305-96-1 |
| Chemical Name: | |
| Synonyms: | ERK5-IN-2;4-(2-bromanyl-6-fluoranyl-phenyl)carbonyl-~{N}-pyridin-3-yl-1~{H}-pyrrole-2-carboxamide;4-(2-Bromo-6-fluorobenzoyl)-N-(pyridin-3-yl)-1H-pyrrole-2-carboxamide;9N8 |
| 分子量: | 388.19 |
| 分子式: | C₁₇H₁₁BrFN₃O₂ |
| SMILES: | FC1=CC=CC(Br)=C1C(C2=CNC(C(NC3=CC=CN=C3)=O)=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ERK5-IN-2 是一种具有口服活性，亚微摩尔效力，选择性的ERK5抑制剂，对ERK5和ERK5 MEF2D的IC50s 分别是 0.82 μM，3 μM。ERK5-IN-2 不与 BRD4 溴结构域相互作用。ERK5-IN-2 抑制肿瘤异种移植生长和 碱性成纤维细胞生长因子 (bFGF) 驱动的基质胶塞血管的生成。 |
| IC50和靶点: | [{name:"ERK5:0.82 μM (IC50)"},{name: "ERK5 MEF2D:3 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
