ERK5-IN-1
Cat. No.：YN350145
CAS No. ：1234479-76-5
| 产品名称: | ERK5-IN-1 |
| CAS No.: | 1234479-76-5 |
| Chemical Name: | 5,11-dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one |
| Synonyms: | ERK5-IN-1; ERK5 IN 1; ERK5IN1; XMD8-85; XMD 8-85; XMD-8-85; XMD885; XMD 885; XMD-885; |
| 分子量: | 459.54 |
| 分子式: | C₂₅H₂₉N₇O₂ |
| SMILES: | O=C1C2=C(C=CC=C2)N(C)C3=NC(NC4=C(OC)C=C(N5CCN(C)CC5)C=C4)=NC=C3N1C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ERK5-IN-1 是一种有效的ERK5抑制剂，IC50为 87±7 nM。ERK5-IN-1 也抑制LRRK2[G2019S]，IC50为 26 nM。 |
| IC50和靶点: | [{name:"ERK5:87 nM (IC50)"},{name: "LRRK2[G2019S]:26 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Deng, X., Elkins, J.M., Zhang, J., et al.Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-onesEur. J. Med. Chem.70,758-767(2013)
Groendyke, B.J., Powell, C.E., Feru, F., et al.Benzopyrimidodiazepinone inhibitors of TNK2Bioorg. Med. Chem. Lett.30(4),126948(2020)
