Ravoxertinib
Cat. No.：YN350173
CAS No. ：1453848-26-4
| 产品名称: | Ravoxertinib |
| CAS No.: | 1453848-26-4 |
| Chemical Name: | 1-[(1S)-1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-2(1H)-pyridinone |
| Synonyms: | GDC-0994 |
| 分子量: | 440.86 |
| 分子式: | C₂₁H₁₈ClFN₆O₂ |
| SMILES: | O=C1C=C(C2=NC(NC3=CC=NN3C)=NC=C2)C=CN1[C@@H](C4=CC=C(Cl)C(F)=C4)CO |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ravoxertinib (GDC-0994) 是可口服的ERK激酶抑制剂，抑制ERK1和ERK2的IC50分别为6.1 nM 和 3.1 nM。 |
| IC50和靶点: | [{name:"ERK1:6.1 nM (IC50)"},{name: "ERK2:3.1 nM (IC50)"},{name: "p-RSK:12 nM (IC50)"}] |
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| Solvent & Solubility: |
Blake, J.F., Burkard, M.E., Chan, J., et al.Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an extracellular signal-regulated kinase 1/2 (ERK1/2) inhibitor in early clinical developmentJ. Med. Chem.59(12),5650-5660(2016)
