DEL-22379
Cat. No.：YN350190
CAS No. ：181223-80-3
| 产品名称: | DEL-22379 |
| CAS No.: | 181223-80-3 |
| Chemical Name: | N-[2,3-dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2-oxo-1H-indol-5-yl]-1-piperidinepropanamide |
| Synonyms: | DEL22379 |
| 分子量: | 444.53 |
| 分子式: | C₂₆H₂₈N₄O₃ |
| SMILES: | O=C(CCN1CCCCC1)NC2=CC=C(NC(/C3=C\C4=CNC5=C4C=C(OC)C=C5)=O)C3=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | DEL-22379 是一种ERK二聚化抑制剂。DEL-22379 易与 ERK2 结合，Kd为低微摩尔水平，即使在低纳摩尔浓度下也可检测到 EL-22379 与 ERK2 结合。DEL-22379 抑制ERK2二聚化，IC50约为 0.5 μM。 |
| IC50和靶点: | [{name:"ERK2:0.5 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Herrero, A., Pinto, A., Colón-Bolea, P., et al.Small molecule inhibition of ERK dimerization prevents tumorigenesis by RAS-ERK pathway oncogenesCancer Cell28(2),170-182(2015)
