Tauroursodeoxycholate
Cat. No.：YN350198
| 产品名称: | Tauroursodeoxycholate |
| CAS No.: | 14605-22-2 |
| Chemical Name: | 2-[[(3α,5β,7β)-3,7-dihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonic acid |
| Synonyms: | 牛磺熊去氧胆酸; TUDCA; UR 906; Taurolite |
| 分子量: | 499.70 |
| 分子式: | C₂₆H₄₅NO₆S |
| SMILES: | C[C@H](CCC(NCCS(=O)(O)=O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tauroursodeoxycholate (TUDCA; UR 906; Taurolite) 是一种内质网应激抑制剂。Tauroursodeoxycholate 显著降低凋亡分子如caspase-3和caspase-12表达。Tauroursodeoxycholate 也抑制ERK。 |
| IC50和靶点: | |
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Beuers, U.Effects of bile acids on hepatocellular signaling and secretionYale J. Biol. Med.70(4),341-346(1997)
Boatright, J.H., Nickerson, J.M., Moring, A.G., et al.Bile acids in treatment of ocular diseaseJ. Ocul. Biol. Dis. Infor.2(3),149-159(2009)
Vang, S., Longley, K., Steer, C.J., et al.The unexpected uses of urso- and tauroursodeoxycholic acid in the treatment of non-liver diseasesGlob. Adv. Health Med.3(3),58-69(2014)
