Honokiol
Cat. No.：YN350219
CAS No. ：35354-74-6
| 产品名称: | Honokiol |
| CAS No.: | 35354-74-6 |
| Chemical Name: | 3',5-di-2-propen-1-yl-[1,1'-biphenyl]-2,4'-diol |
| Synonyms: | 和厚朴酚; NSC 293100 |
| 分子量: | 266.33 |
| 分子式: | C₁₈H₁₈O₂ |
| SMILES: | OC1=C(CC=C)C=C(C2=CC(CC=C)=CC=C2O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Honokiol是一种具有生物活性的双酚类植物化学物质，靶向多种信号分子，具有有效的抗氧化，抗炎，抗血管生成和抗癌活性。 它抑制Akt的活化并增强ERK1/ERK2的磷酸化。Honokiol 能透过血脑屏障。 |
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Maruyama, Y., Kuribara, H., Morita, M., et al.Identification of magnolol and honokiol as anxiolytic agents in extracts of Saiboku-to, an oriental herbal medicineJ. Nat. Prod.61(1),135-138(1998)
Bai, X., Cerimele, F., Ushio-Fukai, M., et al.Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivoJ. Biol. Chem.278(37),35501-35507(2003)
Ahn, K.S., Sethi, G., Shishodia, S., et al.Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-κB activation pathwayMol. Cancer Res.4(9),621-633(2006)
Singh, T., and Katiyar, S.K.Honokiol inhibits non-small cell lung cancer cell migration by targeting PGE2-mediated activation of β-catenin signalingPLoS One8(4),e60749(2013)
Kim, B.H., and Cho, J.Y.Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppressionActa Pharmacol. Sin.29(1),113-122(2008)
Dikalov, S., Losik, T., and Arbiser, J.L.Honokiol is a potent scavenger of superoxide and peroxyl radicalsBiochem. Pharmacol.76(5),589-596(2008)
