Corynoxeine
Cat. No.：YN350229
| 产品名称: | Corynoxeine |
| CAS No.: | 630-94-4 |
| Chemical Name: | (αE,1′R,6′R,7′S,8′aS)-6'-ethenyl-1,2,2′,3′,6′,7′,8′,8′a-octahydro-α-(methoxymethylene)-2-oxo-spiro[3H-indole-3,1′(5′H)-indolizine]-7′-acetic acid, methyl ester |
| Synonyms: | 去氢钩藤碱 |
| 分子量: | 382.45 |
| 分子式: | C₂₂H₂₆N₂O₄ |
| SMILES: | O=C(NC1=C2C=CC=C1)[C@]32[C@@](C[C@H](/C(C(OC)=O)=C\OC)[C@@H](C=C)C4)([H])N4CC3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Corynoxeine, 从Uncaria rhynchophylla的钩中分离的，是 PDGF-BB 诱导血管平滑肌细胞 (VSMCs) 增殖过程中的一种有效ERK1/ERK 2抑制剂。 |
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Yuan, D., Ma, B., Wu, C., et al.Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on NO production in lipopolysaccharide-activated microgliaJ. Nat. Prod.71(7),1271-1274(2008)
Kim, T.-J., Lee, J.-H., Lee, J.-J., et al.Corynoxeine isolated from the hook of Uncaria rhynchophylla inhibits rat aortic vascular smooth muscle cell proliferation through the blocking of extracellular signal regulated kinase 1/2 phosphorylationBiol. Pharm. Bull.31(11),2073-2078(2008)
Xie, Y., Wei, D., Hu, T., et al.Anti-pseudo-allergic capacity of alkaloids screened from Uncaria rhynchophyllaNew J. Chem.4,38-45(2020)
Sakakibara, I., Terabayashi, S., Kubo, M., et al.Effect on locomotion of indole alkaloids from the hooks of Uncaria plantsPhytomedicine6(3),163-168(1999)
