Magnolin
Cat. No.：YN350237
| 产品名称: | Magnolin |
| CAS No.: | 31008-18-1 |
| Chemical Name: | (1S,3aR,4S,6aR)-1-(3,4-dimethoxyphenyl)tetrahydro-4-(3,4,5-trimethoxyphenyl)-1H,3H-furo[3,4-c]furan |
| Synonyms: | 木兰苷 |
| 分子量: | 416.46 |
| 分子式: | C₂₃H₂₈O₇ |
| SMILES: | COC1=C(OC)C(OC)=CC([C@H]2OC[C@]3([H])[C@@H](C4=CC=C(OC)C(OC)=C4)OC[C@@]32[H])=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Magnolin 是Magnoliaflos (Shin-Yi) 的主要成分，靶向作用于ERK1和ERK2，IC50s 分别为 87 nM 和 16.5 nM，从而抑制Ras/ERKs/RSK2信号通路。 |
| IC50和靶点: | [{name:"ERK2:16.5 nM (IC50)"},{name: "ERK1:87 nM (IC50)"}] |
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Kakisawa, H., Kusumi, T., Hsu, H.-Y., et al.Structures of lignans of Magnolia fargesiiBull. Chem. Soc. Jpn.43(11),3631-3631(1970)
Kim, J.Y., Lim, H.J., Lee, D.Y., et al.In vitro anti-inflammatory activity of lignans isolated from Magnolia fargesiiBioorg. Med. Chem. Lett.19(3),937-940(2009)
Lee, C.-J., Lee, M.-H., Yoo, S.-M., et al.Magnolin inhibits cell migration and invasion by targeting the ERKs/RSK2 signaling pathwayBMC Cancer15:576,(2015)
Huang, Y., Zou, X., Zhang, X., et al.Magnolin inhibits prostate cancer cell growth in vitro and in vivoBiomed Pharmacother.87,714-720(2017)
