Loureirin B
Cat. No.：YN350238
| 产品名称: | Loureirin B |
| CAS No.: | 119425-90-0 |
| Chemical Name: | 1-(4-hydroxyphenyl)-3-(2,4,6-trimethoxyphenyl)-1-propanone |
| Synonyms: | 龙血素 B |
| 分子量: | 316.35 |
| 分子式: | C₁₈H₂₀O₅ |
| SMILES: | O=C(C1=CC=C(O)C=C1)CCC2=C(OC)C=C(OC)C=C2OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Loureirin B 是从剑叶龙血树中分离到的黄酮类化合物，为PAI-1的抑制剂，IC50值为 26.10 μM；Loureirin B 同时可以抑制KATP，以及ERK、JNK的磷酸化，具有抗糖尿病的功效。 |
| IC50和靶点: | [{name:"PAI-1:26.1 μM (IC50)'}, 'KATP', 'ERK', 'JNK'] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Yin, S., Hu, Q., Luo, J., et al.Loureirin B, an essential component of Sanguis Draxonis, inhibits Kv1.3 channel and suppresses cytokine release from Jurkat T cellsCell Biosci.4,78(2014)
He, T., Bai, X., Yang, L., et al.Loureirin B inhibits hypertrophic scar formation via inhibition of the TGF-β1-ERK/JNK pathwayCell Physiol. Biochem.37(2),666-676(2015)
Sha, Y., Zhang, Y., Cao, J., et al.Loureirin B promotes insulin secretion through inhibition of KATP channel and influx of intracellular calciumJ. Cell. Biochem.119(2),2012-2021(2017)
