Theaflavin 3,3'-digallate
Cat. No.：YN350239
| 产品名称: | Theaflavin 3,3'-digallate |
| CAS No.: | 30462-35-2 |
| Chemical Name: | 3,4,5-trihydroxy-benzoic acid, 1,1'-[(3,4,6-trihydroxy-5-oxo-5H-benzocycloheptene-1,8-diyl)bis[(2R,3R)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-2,3-diyl]] ester |
| Synonyms: | 茶黄素-3,3'-双没食子酸; TF-3; ZP10 |
| 分子量: | 868.70 |
| 分子式: | C₄₃H₃₂O₂₀ |
| SMILES: | O=C(C1=CC(O)=C(O)C(O)=C1)O[C@H](CC2=C3O)[C@H](OC2=CC(O)=C3)C4=C(C=C([C@@H](OC5=CC(O)=CC(O)=C5C6)[C@@H]6OC(C7=CC(O)=C(O)C(O)=C7)=O)C=C(O)C8=O)C8=C(O)C(O)=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Theaflavin 3,3'-digallate (TF3) 是红茶中的典型色素，一种很好的抗肿瘤剂。Theaflavin 3,3'-digallate 通常被认为是通过影响多种信号转导途径对癌症发生具有抑制作用而无不良副作用，例如上调 p53 和 p21，抑制细胞存活蛋白Akt和MAPK途径的磷酸化，下调NF-κB，改变促/抗凋亡蛋白之间的比例。Theaflavin 3,3'-digallat 导致磷酸-ERK1/2和 -MEK1/2蛋白表达的快速和持续降低。Theaflavin 3,3'-digal |
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Wu, Y.-y., Li, W., Xu, Y., et al.Evaluation of the antioxidant effects of four main theaflavin derivatives through chemiluminescence and DNA damage analysesJ. Zhejiang. Univ. Sci. B.12(9),744-751(2011)
Wu, Y., Jin, F., Wang, Y., et al.In vitro and in vivo anti-inflammatory effects of theaflavin-3,3'-digallate on lipopolysaccharide-induced inflammationEur. J. Pharmacol.794(5),52-60(2017)
Hu, X., Ping, Z., Gan, M., et al.Theaflavin-3,3'-digallate represses osteoclastogenesis and prevents wear debris-induced osteolysis via suppression of ERK pathwayActa. Biomater.48(15),479-488(2017)
