Enniatin B
Cat. No.：YN350253
| 产品名称: | Enniatin B |
| CAS No.: | 917-13-5 |
| Chemical Name: | cyclo[(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-valyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-valyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-valyl |
| Synonyms: | 恩镰孢菌素 B |
| 分子量: | 639.82 |
| 分子式: | C₃₃H₅₇N₃O₉ |
| SMILES: | CC([C@](O1)([H])C(N([C@H](C(O[C@@H](C(N([C@](C(C)C)([H])C(O[C@H](C(C)C)C(N(C)[C@@H](C(C)C)C1=O)=O)=O)C)=O)C(C)C)=O)C(C)C)C)=O)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Enniatin B 是一种镰刀菌毒素。在大鼠肝微粒体酶实验中，Enniatin B 抑制酰基辅酶 A：胆固醇酰基转移酶 (ACAT) 活性，IC50为 113 μM。Enniatins B 可降低ERK(p44/p42) 活化。 |
| IC50和靶点: | |
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Sy-Cordero, A.A., Pearce, C.J., and Oberlies, N.H.Revisiting the enniatins: A review of their isolation, biosynthesis, structure determination and biological activitiesJ. Antibiot. (Tokyo)65(11),541-549(2012)
Kamyar, M.R., Rawnduzi, P., Studenik, C.R., et al.Investigation of the electrophysiological properties of enniatinsArch. Biochem. Biophys.429(2),215-223(2004)
Hiraga, K., Yamamoto, S., Fukuda, H., et al.Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiaeBiochem. Bioph. Res. Commun.328(4),1119-1125(2005)
Tomoda, H., Huang, X.H., Cao, J., et al.Inhibition of acyl-CoA: Cholesterol acyltransferase activity by cyclodepsipeptide antibioticsJ. Antibiot. (Tokyo)45(10),1626-1632(1992)
Wätjen, W., Debbab, A., Hohlfeld, A., et al.Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylationMol. Nutr. Food Res.53(4),431-440(2009)
Dornetshuber, R., Heffeter, P., Kamyar, M.R., et al.Enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cellsChem. Res. Toxicol.20(3),465-473(2007)
