Enniatin B1
Cat. No.：YN350254
| 产品名称: | Enniatin B1 |
| CAS No.: | 19914-20-6 |
| Chemical Name: | cyclo[(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-valyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-valyl] |
| Synonyms: | 恩镰孢菌素 B1 |
| 分子量: | 653.85 |
| 分子式: | C₃₄H₅₉N₃O₉ |
| SMILES: | CC[C@@H]([C@]1([H])N(C([C@H](OC([C@](N(C([C@@H](C(C)C)OC([C@H](C(C)C)N(C)C([C@](C(C)C)([H])OC1=O)=O)=O)=O)C)([H])C(C)C)=O)C(C)C)=O)C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Enniatin B1 是一种镰刀菌毒素。在大鼠肝微粒体酶实验中，Enniatin B1 抑制酰基辅酶 A：胆固醇酰基转移酶 (ACAT) 活性，IC50为 73 μM。Enniatin B1 能透过血脑屏障。Enniatin B1 降低ERK(p44/p42) 活化。Enniatin B1 抑制 TNF-α 诱导的NF-κB激活。 |
| IC50和靶点: | |
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Sy-Cordero, A.A., Pearce, C.J., and Oberlies, N.H.Revisiting the enniatins: A review of their isolation, biosynthesis, structure determination and biological activitiesJ. Antibiot. (Tokyo)65(11),541-549(2012)
Kamyar, M.R., Rawnduzi, P., Studenik, C.R., et al.Investigation of the electrophysiological properties of enniatinsArch. Biochem. Biophys.429(2),215-223(2004)
Wätjen, W., Debbab, A., Hohlfeld, A., et al.Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylationMol. Nutr. Food Res.53(4),431-440(2009)
Hiraga, K., Yamamoto, S., Fukuda, H., et al.Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiaeBiochem. Bioph. Res. Commun.328(4),1119-1125(2005)
