Enniatin A1
Cat. No.：YN350260
| 产品名称: | Enniatin A1 |
| CAS No.: | 4530-21-6 |
| Chemical Name: | cyclo[(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-valyl] |
| Synonyms: | 恩镰孢菌素 A1 |
| 分子量: | 667.87 |
| 分子式: | C₃₅H₆₁N₃O₉ |
| SMILES: | O=C([C@@]([C@@H](C)CC)([H])N(C)C([C@@H](C(C)C)OC(C([C@@H](C)CC)N(C)C([C@@H](C(C)C)OC([C@H](C(C)C)N1C)=O)=O)=O)=O)O[C@@](C(C)C)([H])C1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Enniatin A1 是从镰刀菌霉菌毒素 (Fusarium) 中分离出来的，由交替的 D-α-羟基异戊酸和 N-甲基-L-氨基酸组成的环状十六肽。 Enniatin A1 通过诱导细胞凋亡和破坏ERK信号通路而具有抗癌特性。Enniatin A1 在大鼠肝微粒体中抑制ACAT的IC50为 49 μM。 |
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Sy-Cordero, A.A., Pearce, C.J., and Oberlies, N.H.Revisiting the enniatins: A review of their isolation, biosynthesis, structure determination and biological activitiesJ. Antibiot. (Tokyo)65(11),541-549(2012)
Kamyar, M.R., Rawnduzi, P., Studenik, C.R., et al.Investigation of the electrophysiological properties of enniatinsArch. Biochem. Biophys.429(2),215-223(2004)
Wätjen, W., Debbab, A., Hohlfeld, A., et al.Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylationMol. Nutr. Food Res.53(4),431-440(2009)
