PF-03715455
Cat. No.：YN350276
| 产品名称: | PF-03715455 |
| CAS No.: | 1056164-52-3 |
| Chemical Name: | |
| Synonyms: | PF03715455;PF-03715455;PF 03715455 |
| 分子量: | 700.27 |
| 分子式: | C35H34ClN7O3S2 |
| SMILES: | O=C(NC1N(C2C=C(Cl)C(O)=CC=2)N=C(C(C)(C)C)C=1)NCC1C(SC2C=CC3=NN=C(C4C(SCCO)=CC=CC=4)N3C=2)=CC=CC=1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PF-03715455 是一种有效的吸入的p38 MAPK抑制剂，对p38α有一定的选择性，对p38α和p38β的IC50值分别为 0.88 和 23 nM。PF-03715455 对 LPS 诱导的人全血 TNFα 产生有抑制作用 (IC50=1.7 nM)。PF-03715455 有用于慢性阻塞性肺病 (COPD) 的潜力。 |
| IC50和靶点: | [{name:"p38α:0.88 nM (IC50)"},{name: "p38β:23 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
