H-8 dihydrochloride
Cat. No.：YN450157
| 产品名称: | H-8 dihydrochloride |
| CAS No.: | 113276-94-1 |
| Chemical Name: | N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide, dihydrochloride |
| Synonyms: | H8; H8 dihydrochloride. |
| 分子量: | 338.3 |
| 分子式: | C12H15N3O2S • 2HCl |
| SMILES: | CNCCNS(C1=CC=CC2=CN=CC=C21)(=O)=O.Cl.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | H-8 (dihydrochloride) 是一种细胞可通透的可逆性和 ATP 竞争性的PKA抑制剂。 |
| IC50和靶点: | |
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Engh, R.A., Girod, A., Kinzel, V., et al.Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89 structural implications for selectivityJ. Biol. Chem.271(42),26157-26164(1996)
Hidaka, H., Inagaki, M., Kawamoto, S., et al.Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase CBiochemistry23,5036-5041(1984)
Hagiwara, M., Inagaki, M., and Hidaka, H.Specific binding of a novel compound, N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide (H-8) to the active site of cAMP-dependent protein kinaseMol. Pharmacol.31,523-528(1987)
Rickert, P., Corden, J.L., and Lees, E.Cyclin C/CDK8 and cyclin H/CDK7/p36 are biochemically distinct CTD kinasesOncogene18(4),1093-1102(1999)
