FIDAS-3
Cat. No.：YN450163
CAS No. ：1266684-01-8
| 产品名称: | FIDAS-3 |
| CAS No.: | 1266684-01-8 |
| Chemical Name: | 4-[(1E)-2-(2,6-difluorophenyl)ethenyl]-N,N-dimethyl-benzenamine |
| Synonyms: | |
| 分子量: | 259.2938464 |
| 分子式: | C16H15F2N |
| SMILES: | CN(C)C(C=C1)=CC=C1/C=C/C2=C(C=CC=C2F)F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | FIDAS-3 是一种二苯乙烯衍生物，也是一种强效的Wnt抑制剂，对甲硫氨酸腺苷转移酶 2A (MAT2A) 的IC50为 4.9 μM。FIDAS-3 与 S-腺苷甲硫氨酸 (SAM) 有效竞争MAT2A结合，并具有抗癌活性。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Sviripa, V.M., Zhang, W., Balia, A.G., et al.2',6'-Dihalostyrylanilines, pyridines, and pyrimidines for the inhibition of the catalytic subunit of methionine S-adenosyltransferase-2J. Med. Chem.57(14),6083-6091(2014)
Zhang, W., Sviripa, V., Chen, X., et al.Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2AACS Chem. Biol.8(4),796-803(2013)
Zhang, W., Sviripa, V., Kril, L.M., et al.Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repressionJ. Med. Chem.54(5),1288-1297(2011)
