NSC668036
Cat. No.：YN450165
| 产品名称: | NSC668036 |
| CAS No.: | 144678-63-7 |
| Chemical Name: | N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-(2S)-2-hydroxy-3-methylbutanoyl-L-alanine, (1S)-1-carboxy-2-methylpropyl ester |
| Synonyms: | NSC 668036 |
| 分子量: | 460.5 |
| 分子式: | C21H36N2O9 |
| SMILES: | CC(C(OC(C(C)NC(C(C(C)C)OC(C(C)NC(OC(C)(C)C)=O)=O)=O)=O)C(O)=O)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NSC668036 是一种Disheveled (Dvl) PDZ结构域抑制剂，Kd为 237 µM。NSC668036 通过中断 Frizzled-Dvl 相互作用来阻断Wnt信号。 |
| IC50和靶点: | |
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Shan, J., Shi, D.-L., Wang, J., et al.Identification of a specific inhibitor of the dishevelled PDZ domainBiochemistry44(47),15495-15503(2005)
Wang, C., Dai, J., Sun, Z., et al.Targeted inhibition of disheveled PDZ domain via NSC668036 depresses fibrotic processExp. Cell Res.331(1),115-122(2015)
