FzM1
Cat. No.：YN450167
CAS No. ：1680196-54-6
| 产品名称: | FzM1 |
| CAS No.: | 1680196-54-6 |
| Chemical Name: | N-[3-hydroxy-5-(2-thienyl)phenyl]-N'-2-naphthalenyl-urea |
| Synonyms: | Fzd4 modulator FzM1;FzM 1 |
| 分子量: | 360.4 |
| 分子式: | C21H16N2O2S |
| SMILES: | O=C(NC1=CC(O)=CC(C2=CC=CS2)=C1)NC3=CC4=CC=CC=C4C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | FzM1 是卷曲蛋白受体FZD4的负变构调节剂 (NAM)。 FzM1减少 WNT5A 依赖的WNT反应元件 (WRE) 活性 (log EC50inh=-6.2)。 FzM1 与位于 FZD4 细胞内环 3 (ICL3) 的变构结合位点结合并改变受体的构象，最终抑制 WNT/β-连环蛋白级联反应。 |
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